Goat plague is a viral disease of goats and sheep characterized by fever, sores in the mouth, diarrhea, pneumonia, and sometimes death. This disease is also known as PPR or Ovine rinderpest. Cattle and several wild ruminants have been infected most often experimentally, but goats and sheep are the usual targets. All the sheep and goats of the affected flock should be under quarantine for at least 1 month after the last clinical case. Animal movements have to be strictly controlled in the area of the infection. There is no specific treatment for this disease. However, treatment of affected animals by administration of antibiotics (long-acting oxytetracycline, chlortetracycline) to prevent secondary bacterial infections and anti-diarrheal medicines has been practiced with supportive therapy (chloramphenicol, penicillin, and streptomycin) for 5–7 days, which may be useful to reduce the severity of the disease. If temperature is higher (106 degrees) than no multi vitamins are used.