Cotton Leaf Curl Disease is among the most destroying viral catastrophe that causes tremendous loss to cotton yield particularly in Pakistan during the past 20 years.The significant vector for spreading of this sickness is white fly. So by controlling white fly, this disease can be controlled in real terms.The CLCuD can be managed by control of vector whitefly and eradication of weeds that contribute as a host of cotton leaf curl virus. Different agronomic practices like sowing time and use of supplements (Nitrogen and Potassium) can minimize the disease impact. Appropriate sowing time ideally mid-April to mid-May brings about reduction of disease impact. In the case of planting later than 15th of June, the recommended plant to plant spacing is 15 cm in order to manage CLCuD. The influence of Potassium (K) application on disease through specific metabolic functions alters the relationship of host-parasite interaction. An investigation indicated that by increased use of Potassium up to 250kg/ha brings about the reduction of this viral attack from 12 to 38%. Also the seed cotton yield increased up to 37% by increased application as compared to Zero-K. All the previously mentioned measures of controlling CLCuD can be implemented relying on the conditions. Development of resistance varieties alongside Agronomic, fertilizer, insecticidal control and biotechnological techniques can be utilized alone and in combination to control this extreme disease impact which is yet a challenge even after twenty years of broad research.